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This experiment was repeated seven times independently to generate a robust list of differentially expressed genes and to be able to detect modest changes in gene expression with good probability.
FISH, in contrast, has single cell resolution and, thus, is more sensitive and able to detect modest gene copy number changes that could involve only a minority of the tumour cells.
Similar(57)
In the wider studies of Ca2+ signaling in our laboratory, we are routinely able to use such indicators to detect modest Ca2+ rises of ∼10 nM amplitude, which represents a 0.1-fold change in Ca2+ concentration over baseline and is typically >2 times the standard deviation of the basal signal.
Notably, we were unable to reproduce the reported sensitivities of recF, recJ, recQ and sbcC strains, and were only able to detect a modest sensitivity of a recN strain.
Nevertheless, in parenchymal JNK1-deficiency, we were able to detect a modest JNK activity in the WT→Jnk1−/− but not in the Jnk1−/−→Jnk1−/− chimeras, confirming the WT cell deposition in the adipose tissue and the potential impact of bone marrow transplantation.
CT densitometry is able to detect rather modest (~50%) increases in EVLW in experimental animals [ 17].
Perhaps the dilution in relatively large cells was too effective to detect modest contributions of tracer through preferential flow paths.
Forth, our relatively small sample size may not sufficiently powerful to detect modest association.
5 However, the study was underpowered to detect modest effects.
Thus, we were not well-powered to detect modest risks.
Second, the sample size was too small to detect modest changes in glycemic control.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com