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Previously, it was reported that HBx was able to decrease the expression of PTEN [25].
It is suggested that AvrA expression in the WT Salmonella is able to decrease the expression of inflammatory cytokine IL-6.
CtBP interacts with TCF-4, histone deacetylases and is able to decrease the expression of the endogenous Wnt targets [ 20].
Conversely, restoration of WISP3 expression in the highly malignant IBC cell line SUM149 was able to decrease the expression of RhoC protein.
In a previous study, functional in vitro analyses performed in lymphoblastoid cell lines provided evidence that hsa-miR-127 was able to decrease the expression of BLIMP-1 and XBP-1 in a dose-dependent fashion, resulting in a consequent overexpression of BCL-6.
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Interestingly, the delayed treatment with Hemin was also able to reduce renal dysfunction and to decrease the expression of pro-inflammatory molecules, all in association with significantly reduced levels of fibrosis-related molecules and collagen deposition.
The anti-CD74 antibody was also able to decrease the surface expression of β7-integrin as well as CD62L, mainly on CD27- naïve B cells in vitro.
As shown in Supplementary Figure S3, we were able to decrease the myxothiazol-induced expression of ATF4 mRNA by >80% using two separate shRNA targeting its different regions of ATF4 mRNA, compared with a scrambled shRNA control.
However, this mutant was not able to decrease the AP-2α expression in either of the CREB-silenced cell lines (Figure S2).
Taken together, our experimental data indicate that expression of both the p.Ser59Leu and p.Pro34Ser CHCHD10 mutations is able to decrease the sensitivity of the cells toward apoptotic stimuli.
In contrast, E2 treatment was only able to decrease the frequency of neutrophils in the joints of WT littermates, whereas the neutrophils were unaffected by E2 treatment in mice lacking ERα expression in chondrocytes.
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