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Thus, much effort has been invested in the development of disease modifying drugs able to block key mediators within the cartilage matrix and biochemical pathways inside chondrocytes.
With regard to positive regulation, we also have observed that Mf-1 is able to block key histone modifications (e.g., H3K9Ac and H3K4Me3) in several positively-regulated endogenous target genes in α-23 cells (Wang and Yen, unpublished results).
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To evade this surveillance mechanism, virtually all plant viruses are known to encode suppressor proteins that are able to block different key steps of the PTGS pathway (Ding and Voinnet, 2007).
The LDP and other opposition parties control the upper house, enabling them to block key legislation.
The Senate voted Tuesday to block key pillars of President Barack Obama's climate change agenda.
With the four senior ministers in the budget discussions due to speak on Friday and a final meeting scheduled for Monday, the Liberal Democrats appear to recognise that they are not going to be able to block what is Osborne's key demand for the budget, but are trying to maximise the concessions they can extract in return.
We tested this notion using drugs targeting these key pathways and demonstrated clear differences in the extent to which different drugs are able to block mesenchymal transition induced by different triggers.
Congress may not be able to block the Gulfport project.
They say they will be able to block the plan.
She had always been able to block every ball back.
"To be able to block for your son is priceless".
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