The consequences of IRI are not only the initial ablation of functioning nephrons, but also the activation of the immune response 4– 6.
Similar to germline ablation, loss-of-function mutations in daf-2, which encodes the sole C. elegans insulin/insulin-like growth factor receptor family member (InsR) (Kimura et al. 1997), extend C. elegans life span in a DAF-16/FoxO-dependent manner (Kenyon et al. 1993).
Furthermore, JmjD6 plays an important role during heart development since ablation of its function is associated with complex cardiopulmonary malformations that resemble the human congenital heart syndrome tetralogy of Fallot [ 289].
Furthermore, Ptdsr plays an important role during heart development and ablation of Ptdsr function is associated with complex cardio-pulmonary malformations that resemble the human congenital heart syndrome Tetralogy of Fallot [ 55].
Duong, T. et al. Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice.
In contrast, knockout mouse models involve complete ablation of gene function, abolishing any activity of the corresponding protein.
Ablation of macrophage function, or inhibition of their infiltration into experimental tumors, inhibits growth and metastases, strongly suggests that macrophages are involved in promoting tumor progression [43].
Ablation of p53 function can restore the survival of pre-TCR-deficient thymocytes, but at later time points these cells consistently give rise to lymphomas [32], [34], [35].
Positive correlation between brown vs. white preadipocytes signature and SNF5 perturbation implies that ablation of SNF5 function induces gene expression changes that are positively correlated with white preadipocytes.
In spite of the absence of a more dramatic effect in virulence by ablation of septin function, we concentrated our efforts to determine whether absence of septins would affect the formation of the infective filament in U. maydis.
