The phrase "ability to upregulate the expression of" is correct and usable in written English.
It can be used in scientific or technical contexts, particularly in discussions about gene expression or cellular processes.
Example: "The research focused on the ability to upregulate the expression of specific genes in response to environmental changes."
Alternatives: "capacity to enhance the expression of" or "potential to increase the expression of".
Angiogenic function of S100A4 was associated with its ability to upregulate the expression of several MMPs and downregulate their inhibitors (TIMPs) (Schmidt-Hansen et al, 2004b).
We further demonstrate that PKC η promotes senescence through its ability to upregulate the expression of the cell cycle inhibitors p21Cip1 and p27Kip1 and enhance transcription and secretion of interleukin-6 (IL-6).
Adora2a −/− thio-pMacs lost their ability to upregulate the expression of Nr4a1 and Thbs1 genes in response to the apoptotic cell supernatant, confirming the essential role of the A2a receptor in this process.
Proangiogenic effects of leptin can be further potentiated by its ability to upregulate the expression of other angiogenic factors, such as VEGF, bFGF, interleukin 1-β, and leukemia inhibitory factor in cancer cells [ 18, 29- 31].
Mice deficient for both p53 and TAp73 maintain a similar basal expression of TIGAR to WT animals and retain the ability to upregulate the expression of TIGAR in the crypts of the small intestine following tissue ablation.
Here we show that PKC η promotes senescence induced by oxidative stress and DNA damage via its ability to upregulate the expression of the cell cycle inhibitors p21Cip1 and p27Kip1, and create a positive loop for reinforcing senescence by enhancing the expression of both interleukin-6 (IL-6) and its receptor.
We previously reported that autophagy-defective mutants cannot maintain the amino acid pool needed for protein synthesis, and this impairs the ability of cells to upregulate the expression of starvation-induced genes [4].
Importantly, FOXM1 depletion by shRNA significantly abolished the ability of MEIS2d to upregulate the expression of mitotic genes, demonstrating that FOXM1 is an essential mediator of MEIS2 action in neuroblastoma cells.
However, the present study demonstrated that inactivation of PI3K using LY294002 or a siRNA attenuated the ability of VPA to upregulate the expression of MICA and MICB in pancreatic cancer cells.
This phenomenon is a result of the ability of estrogen deficiency to upregulate the expression of major histocompatibility complex II and the costimulatory molecule CD80.
Davies tested the ability of α-tocopherol at high concentrations to upregulate the expression of PPARγ.
