The HAb18G/CD147-specific siRNA (siCD147) and sncRNA were tested for their ability to specifically suppress HAb18G/CD147.
The importance of HAUSP in cells was demonstrated by its ability to specifically recognize and deubiquitinate both the tumor suppressor p53 and Mdm2, a p53-specific E3 ligase.
Professor Paul Workman, chief executive of the ICR said: "We may normally think of viruses as the enemies of mankind, but it's their very ability to specifically infect and kill human cells that can make them such promising cancer treatments".
There's also the ability to specifically search for "Nearby" updates.
Lectins form a diverse group of protein families that have in common their ability to specifically recognize certain carbohydrates.
Important criteria for such peptides include their ability to specifically perturb a defined protein-protein interaction and to be sufficiently soluble to permit microinjection.
These functional coatings should have the ability to specifically bind (bio molecules with a high binding efficiency, while showing low unspecific binding during the following assay.
Magnetic particles, functionalized with transition metal ions, possess the ability to specifically bind recombinant proteins engineered to contain C- or N-terminal histidine residues (e.g., a hexahistidine tag).
Rat monoclonal antibodies were raised and selected for their ability to specifically recognize a surface antigen for the A. minutum strain AM89BM from the Bay of Morlaix, France.
They have been successfully used in antisense technology, for their ability to specifically bind to messenger RNA (mRNA) targets and to inhibit translation of the target genes.
The ability to specifically deliver therapeutic agents to selected cell types while minimizing systemic toxicity is a principal goal of nanoparticle-based drug delivery approaches.
