Their ability to recapitulate facets of normal human development during in vitro morphogenesis produces tissue structures with unprecedented biomimicry.
We previously established the ability to recapitulate these natural histone tail activities within non-viral nanocarriers, improving gene transfer and expression by enabling effective navigation to the nucleus via retrograde vesicular trafficking.
In summary, we have designed a multilayer engineered ovarian tissue that secretes sex steroids and peptide hormones and responds to gonadotropins, thus demonstrating the ability to recapitulate native ovarian structure ex vivo.
However, many organoid differentiation protocols are inefficient and display marked variability in their ability to recapitulate the three-dimensional architecture and course of neurogenesis in the developing human brain.
The ability to recapitulate aspects of human developmental processes in vitro using hESC[4] is of significant interest.
Embryonic stem (ES) cells derived from blastocysts retain the ability to recapitulate neural development in vitro, and offer an invaluable model to study early events in embryogenesis.
To explore the utility of cell chip technology for pathway analysis, we examined the chip's ability to recapitulate the interferon response of A549 cells.
These cell lines have undergone extensive characterization of their tumorigenic potential and invasion capacity [14], [47], and have been shown to possess a remarkable ability to recapitulate the clinical stages of disease from which they were derived.
This conclusion is based on our own ability to recapitulate their performance using a simple method that also uses a noise model to infer connections (see analysis of null-mutant Z-scores below).
We did, however, observe an ability to recapitulate the serous EOC clustering using an abbreviated 7-gene signature that included CLDN1, CYR61, FN1, IL-8, MUC1, TNC and THBS1.
