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This T-cell hyporesponsiveness due to defects of signalling through the TCR either from healthy elderly subjects or from individuals with autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus results in an impaired ability to mount efficient immune responses and to maintain responsiveness to foreign antigens.
T-cell hyporesponsiveness due to defects of signalling through the TCR either from healthy elderly subjects or from individuals with autoimmune diseases such as RA and SLE results in an impaired ability to mount efficient immune responses and to maintain responsiveness to foreign antigens.
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The ability to mount an efficient immune response varies with age, showing a weaker response during the first years of life [10], [13], [14], [78]; b) ethnic groups.
Embryos of most fish develop externally and are exposed to an aquatic environment full of potential pathogens, whereas they have little or only limited ability to mount an efficient and protective response.
Kidney cells, as T-lymphocytes, are normal primary cells with a very different molecular make-up from cancer cells, especially concerning their ability to mount an efficient innate immune response, which is irreparably compromised during malignant transformation.
This finding confirms the very recent data published by Benson et al. [22] showing that treatment of antigen primed mice with TACI-Ig or BAFF-R-Ig does not impair their ability to mount an efficient recall response.
Temperature can modulate the host's ability to mount an effective immune response (Lazzaro and Little 2009).
This suggests that genetic variability may indeed affect this species' ability to mount an effective immune response.
The ability to mount robust CD8 T-cell responses against most pathogens depends upon efficient presentation of antigen by dendritic cells (DCs).
By contrast, there is relative preservation of the ability to mount humoral immune responses.
These disabilities, singly or in league, can impair the accused's ability to mount a defense.
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