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The biochemical function of Hairy is associated with long-range chromatin modifications, which endow this factor with the ability to interfere with multiple cis-regulatory regions, including activators bound over 1 kb distal to the Hairy binding sites.
The effect of curcumin is in part due to its ability to interfere with multiple signaling cascades such as cell cycle regulators, apoptotic proteins, pro-inflammatory cytokines, proliferative regulators and transcription factors such as nuclear factor-kappa B (NF-κB) and Stat3 [ 27].
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It has been reported that the NS1 gene of IAV has the ability to interfere with IFN expression and to function through multiple mechanisms (Hale et al., 2008); however, IFN and downstream targets of IFN signaling are still commonly shown to be induced upon IAV infection (García-Sastre, 2002; García-Sastre, 2011).
SMN is noted for its ability to interfere with apoptotic signaling while acting as an antioxidant.
No country has had either the incentive or the ability to interfere with U.S. shipping.
HSPs inhibit apoptosis through their ability to interfere with mitochondria.
Mechanistically curcumin shares with aspirin the ability to interfere with levels of functional cyclooxygenase (COX) enzymes.
In the first assay, hMLH1-Gly67Glu abolishes the protein's ability to interfere with MMR in yeast.
"With a nuclear program, and an ability to interfere throughout the region, it's basically calling the shots.
We further tested the ability of macitentan to interfere with these process.
- HSP90AA1 inhibitors are now a major focus of cancer therapies and as novel compounds because their ability for interfering with multiple oncogenic pathways is thought to confer a broad antitumor activity and less susceptibility to acquired drug resistance.
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