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This remarkable ability to induce efficient phagocytosis is likely to be a specific adaptation of these parasites to infect various cell types and propagate the infection in the mammalian host.
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Recently, for the first time, Gan et al (2008) have identified a molecular mechanism used by virulent mycobacteria at this late stage to induce efficient MF death but escape MF-mediated killing and maintain their ability to replicate within the granuloma.
In vitro testing showed the diabody's ability to induce an efficient lysis of PSMA-expressing target cells by human PBL.
Notably, Cp#1 and Cp#3 were an order of magnitude more potent in H9 cells, compared with CXCR3 transfectants, which may reflect their ability to induce more efficient coupling of CXCR3 to human G proteins or that CXCR3 expression levels were higher in this cell line.
In contrast to irradiation, 32Hc required DNA-PKcs kinase activity to induce efficient H2AX phosphorylation.
CCL2's ability to induce monocytes to migrate is enhanced by its binding to versican, due to the efficient formation of chemokine gradients and protection from proteolytic degradation.
Accordingly, DC treated with Src inhibitors are not compromised in their ability to induce CD4 T cell proliferation and to promote the Th17 subset survival but are less efficient in inducing Th1 differentiation.
As early gastrula anterior endoderm is required for efficient cardiogenesis in Xenopus embryos and explants [2], we examined its ability to induce cardiac fate in pluripotent animal caps, which normally give rise to ectodermal derivatives and acquire an epidermal character when cultured alone.
Skeletal regeneration and tissue engineering strategies rely critically on the efficient expansion of progenitor cell populations whilst simultaneously preserving multipotentiality and the ability to induce differentiation towards bone and cartilage.
Although DNA vaccines appear to be efficient at inducing strong cellular immune responses, a number of questions remain regarding their ability to induce humoral immunity.
Oncogene, genetic material that carries the ability to induce cancer.
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