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Exact(33)
This study explored new methods for signal detection, intending to decrease background noise while maintaining the ability to detect true signals.
While considering the design of a microarray experiment, the sources of biological and technical variability must be considered as they affect the ability to detect true gene expression changes.
This fact underscores their ability to detect true ecological patterns and is evidence for their methodological robustness.
Moreover, the limited number of hospitalizations observed reduced our ability to detect true effects on this outcome.
The study population is small, limiting its ability to detect true differences that may still exist.
In other words, our ability to detect true character correlations in evolutionary history may be compromised.
Similar(27)
Results from the most restricted backgrounds, the drug classes, were not satisfying for signal detection purposes, as their ability to detect true-positive SDRs was poor; this also confirmed the inherent feature of all signal detection methods in that the lack of detection of an SDR does not imply a lack of a causal relationship between a drug and a reported ADR.
Using this threshold, the sensitivity (ability to detect true-positive compounds) of this approach is 73%, whereas the specificity (ability to detect true-negative compounds) of this approach is 86%.
For all drugs, the ability to detect true-positive SDRs using the PRR-SDR5 was generally lower than for the PRR-SDR3 and the PRR-TAs.
Analyses restricting the background down to drug class (models 4, 7, 8) were not considered relevant to include in this analysis based on their poor performance regarding the ability to detect true-positive SDRs and remove false-positive SDRs.
The PRR-TA performed better or equally well regarding its ability to detect true-positive SDRs and to reduce the noise in the form of false-positive SDRs, compared to the conventional PRR.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com