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Exact(23)
In fact, in most cases there was a loss in cross-linking efficiency and some Protein Z variants lost the ability to cross-link IgG altogether.
These results suggest that our isotopically labeled cross-linkers are indeed comparable in their ability to cross-link proteins and that the resulting d0- and d10-labeled cross-linked products behave similarly during sample preparation and MS n analysis, thus providing flexibility of using these isotope-coded reagents in XL-MS studies.
Cyclophosphamide was widely reported as an anticancer agent due to its ability to cross-link with DNA double strands that leads to the DNA backbone's breakage [91, 92].
Yves-Alexandre de Montjoye, one of the authors of the Nature article, says that the ability to cross-link data, such as matching the identity of someone reading a news article to posts that person makes on Twitter, fundamentally changes the idea of privacy and anonymity.
It is highly likely, however, that the ability to cross-link other DNA binding proteins is also limited by the intrinsic temporal constraints on crosslink chemistry.
When fibroblasts were treated with AG, which is known to inactivate 3DG's ability to cross-link collagen, the activity of caspase-3 was reduced to levels observed in fibroblasts grown on native collagen.
Similar(37)
The Dermelect Web site says that ProSina features an "active form" of an amino acid that gives the product the ability to "cross link with the keratin in nails, resulting in the integrity and cohesion of the nail plate".
This reticulate structure has an ability to cross link on addition of polyvalent cations to from insoluble meshwork.
2. Bladder Health: PACs have a unique ability to cross link or attach to the lining of the bladder and urinary tract, thus inhibiting the attachment and growth of bacteria, including E. Coli, a common cause of urinary tract infections.
The ability of rhPEPD to cross-link two ERBB2 monomers represents a new ERBB2-binding mechanism, as neither trastuzumab nor pertuzumab (another therapeutic anti-ERBB2 monoclonal antibody) cross-links ERBB2 monomers (Cho et al., 2003, Franklin et al., 2004).
If so, the ability of cisplatin to cross-link K protein to DNA may be one of the mechanisms by which this chemotherapeutic agent inhibits processes that compose transcription and replication (Samuel et al, 1998).
Related(20)
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