We did not observe metabolite-induced aggregate formation in subthreshold PolyQ19 or GFP only strains (data not shown), indicating that the metabolite alters the ability of threshold-state animals to handle polyQ misfolding.
The ability of the threshold and non-threshold versions of the models to predict the observed relationships between the tree population dynamics and the nitrogen cycle was determined by calculating and comparing the relative AIC weights of the threshold versus non-threshold versions of the plant-nitrogen cycle models.
Individuals who possess higher levels of natural ability than the threshold level will enter into the complex sector.
Proposition 3 states that individuals who have greater natural ability than the threshold are strictly richer if they enter into the complex sector than they would have been had they entered the simple one.
The threshold ability level below which it is not in the interest of the young individual to pay for the search cost is determined by equalizing the expected gains and costs of occupying a complex position: a t − 1 i b t − 1 = φ b t ⇒ a t − 1 i ∗ = φ b t b t − 1 (8).
Previously, Young, Collier, and coworkers identified that CMG2 G153 and L154 are key residues related to the difference in PA binding ability and pH threshold [26].
Evans and colleagues applied the score approach and assessed the discriminative ability for several threshold levels of statistical significance in several complex diseases [ 15].
For a continuous-scaled marker, the ROC curve graphically depicts the method's discriminatory ability for all threshold values in a unit square by plotting the proportion of true positives (sensitivity) versus the proportion of false positives (1−specificity).
As expected, the thresholds of the 2-category were in the higher ability range, while thresholds of the 1-category were in the lower ability range.
