One of the major factors that determines the ability of substances to penetrate the skin is the size of the molecule.
In recent years there has been considerable concern over the ability of substances discharged into the environment to disrupt the normal endocrine function of wildlife.
Factors, such as anatomical site, age, sex and skin disease influence the consistency of the epidermis and consequently the ability of substances to penetrate the skin barrier.
Since the early 1980s, there has been growing concern about the ability of substances discharged into the environment to disrupt the normal endocrine (hormone) function of wildlife.
Current studies generally focus on the ability of substances to inhibit prostate cancer development, and the NTP needs perhaps to place a greater emphasis on exploring the use of the TRAMP and other models to identify substances that enhance prostate carcinogenesis.
Since the terms antigenicity and immunogenicity are sometimes used imprecisely, it seems useful to specify that, in this report, immunogenicity refers to the ability of substances, e.g., protein conjugates of mPEG, HO-PEG, or t-butoxyPEG (t-BuO-PEG), to induce the production of antibodies in experimental animals or in humans.
Acute toxicity means the ability of a substance to cause adverse effects within a short period following dosing or exposure, which is usually the first step in the toxicological investigations of unknown substances.
When the vasomotor responses from our experiments are compared with the migrainogenic properties of the tested substances, there seems to be little correlation between the ability of a substance to induce migraine-like attacks and their vasoactive properties in human meningeal arteries.
While it appears reasonable to posit that a substance will reach the SPG with an image-guided injection, the ability of a substance to passively diffuse and reach the SPG after intranasal application is uncertain.
The aim of the present study is to evaluate whether there is a connection between the ability of a substance to dilate meningeal arteries and the previously reported migrainogenic properties of each substance.
