Having shown a striking difference between the CRC and non-CRC cell lines, with respect to aspirin effects on NF κB signalling and apoptosis, we investigated potential factors that might contribute to the ability of specific cell types to undergo apoptosis.
Although the hypothesis remains controversial (Lawson et al, 2009; Rosen and Jordan, 2009), putative CSCs have been identified in human cancers, including breast cancer, on the basis of the ability of specific cell populations to initiate tumour formation when transplanted into xenograft models.
The nanofibrillar scaffold created from the Dioscorea opposite extract and its ability to sustain the attachment of specific cell types demonstrate the potential for this natural nanomaterial in tissue engineering applications.
In conclusion, these data confirm Zot as a good mucosal adjuvant, considering its ability to interfere with the suppression of specific cell mediated immunity, probably as a result of the increased dose and/or altered processing of Ag at mucosal level.
Tissue-specific stem cells that reside in differentiated tissues are important in growth and development because they also have the capacity for self-renewal and the ability to differentiate into a variety of specific cell types.
His concept that the same microRNAs could be involved in both the CSC phenotype and the ability of specific cancer cells to give rise to metastases represents a mechanistic link between the initial and the final steps of tumorigenesis [ 5].
Researchers continue to investigate stem cells in mature tissues and demonstrate the potential ability of organ-specific cells to differentiate into multiple lineages.
These results indicate that Ff-hiPSCs cultured under Xf conditions have the ability to differentiate into specific cells of interest using established in vitro induction protocols, with some minor modifications to maintain the Xf conditions.
We hypothesise that a specific relationship may exist between the number and recruitment ability of specific bone marrow-derived cell populations and specific end-stage lung disease pathologies.
The ability of specific p53 mutants to promote tumor growth was demonstrated in cells, in animal models and was correlated with clinical prognosis7,8,9,46.
"The near-term advances will be opportunistic, such as taking advantage of some intrinstic ability of siRNAs to accumulate in specific cell types or tissues.
