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Its impact on the organism depends on the type of oxidant, on the site and intensity of its production, on the composition and activities of various antioxidants, and on the ability of repair systems [ 93].
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This study aimed to investigate whether different irrigation regimens would alter the sealing ability of repaired furcal perforations.
The motion of the WH domain in DrRecQ may allow the WH domain to easily interact with different DNA substrates or to cope with HRDC domains as the DNA is unwinding, which seems to contribute to the remarkable ability of repairing DNA damage in this extremophilic organism.
The crack was more and more difficult to be repaired with the increase of average crack width and the repair ability of microbial repair agent was limited for specimens with crack width up to 0.8 mm.
A study on the BD-exposed workers of Ningbo, China, examined the polymorphic variants in DNA repair genes, assuming that the ability of DNA repair that is different between individuals can modify the genotoxic effect of BD exposure [ 10].
We further analyzed the ability of DSB repair when MS2-CtIP was overexpressed, by performing immunostaining of γ-H2AX staining.
Besides promoting the phenotypic shift of chondrocytes and cartilage destruction [ 52], an impairment of CPC recruitment could compromise the ability of endogenous repair.
This may be related to the increased ability of the repair machinery or amount of the enzymes in the cells, which needs to be addressed in future.
These genetic mutations affect the ability of DNA repair pathways to function after radiation damage, hence affecting the α/β ratio.
However, functional studies demonstrating the ability of DNA repair mechanisms in dealing with insults resulting from hyperglycemia during pregnancy need to be developed.
Coculture with BM showed the ability of damage repair by human islets resulting in functional insulin release from islets in the long term.
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