In this context, the ability of dose monitoring by cumulating the dose, fraction after fraction, is an important step for the implementation of the dose-guided ART strategy.
The ability of dose escalation to induce rash is suggestive of a dose-response relationship; however, this relationship did not extend to efficacy.
However, the ability of doses of IL-15 higher than those experienced during exercise to mediate changes in skin mitochondrial function remains questionable, as levels higher than 10 pg mL−1 did not stimulate mitochondrial respiration in dermal fibroblasts.
Remarkably, mitogenicity inversely correlates with the ability of PGE2 doses to raise cAMP levels.
We compared the ability of different dosing regimens to achieve the target neuroprotective Epo exposure levels determined from animal models of hypoxic-ischemia (i.e., area under the curve during the first 48 h of treatment (AUC48 h) 140,000 mU*h/ml).Birth weight scaled via allometry was a significant predictor of Epo clearance and volume of distribution (P < 0.001).
This group investigated the ability of lower dosing to produce an improved adverse event profile.
The ability of each dosing regimen to achieve predefined pharmacodynamic targets in both patients, that is, vancomycin concentration of at least 20 mg/L, was also assessed.
Interestingly, similar to the effect of SR46349-R, high dose M100907 (3 mg/kg) potentiated the ability of high dose haloperidol (1 mg/kg) to increase DA release in the mPFC and NAC (Figure 5 ).
Moreover, anandamide was shown to exert an appetite stimulating effect even at a very low dose (0.001 mg/kg).93 Therefore, the ability of low doses of this endocannabinoid to improve food intake and to reverse some of the neurotransmitter changes caused by diet restriction, could represent a future therapeutic potential in the treatment of cachexia-associated diseases in humans.
Based on its ability of low-dose IR to induce protein phosphorylation, we hypothesized that low-dose IR counteracted the pro-apoptotic effect of bevacizumab by activating VEGF receptor-2 (VEGFR-2).
