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We examined AR binding affinities of our compounds in a competitive binding assay with a radiolabeled high affinity AR ligand, 3H-mibolerone, and also measured their abilities to stimulate AR-mediated transcriptional activation in a cotransfection assay.
In additions, several literatures have shown that the GL polysaccharide-rich fractions exhibited abilities to stimulate the productions of IL-1, IL-6, IL-12, IFN-γ, tumor necrosis factor-α, IL-6, colony stimulating factor, and nitric oxide, which resulted in the stimulation of splenocyte proliferation and macrophage phagocytosis (Ohno et al. 1998; Mao et al. 1999; Chen et al. 2004).
We mutate the critical cysteines involved in oxidized MPYS homodimer formation and examine their abilities to stimulate IFNβ promoter.
Surprisingly, the total levels of bile salts in cecal extracts from untreated and clindamycin-treated mice were similar despite their differing abilities to stimulate CFU recovery from spores.
Similarly, cholestyramine treatment of the cecal and small intestinal extracts from the clindamycin-treated mice and the small intestinal extracts from the untreated mice severely decreased their abilities to stimulate colony formation from C. difficile spores (Fig. 3).
Cecal extracts from all of the antibiotic-treated mice showed roughly equal abilities to stimulate colony formation from C. difficile spores, which was about 50− to 65-fold higher than cecal extracts from the untreated mice (Fig. 1A and B).
Similar(44)
Later, Upski sounded no less confident of his ability to stimulate change.
Her range of stimuli (and thereby her ability to stimulate others) was extraordinary.
A wealth of evidence reveals vitamin C to have the ability to stimulate and support the immune system.
"Confidence in the efficacy of monetary policy might also be damaged, limiting policymakers' ability to stimulate the economy in future.
That was Liverpool's heaviest defeat since 1963 and compounded doubts about Rodgers ability to stimulate an upswing in performances.
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