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The aCGH data demonstrate that SUM149PT cells have a high number of chromosomal aberrations throughout their genome.
Moreover, it would not be unreasonable to assume that the defects that arise in the aged ETP, could also lead to the acquisition of further aberrations throughout thymopoiesis.
Until recently, multiple gene rearrangements and even genomic landscapes which reflect the structural aberrations throughout the genomes have been identified in multiple types of epithelial cancers, including prostate cancer [ 5, 6], breast cancer [ 7, 8], lung cancer [ 9, 10], colorectal cancer [ 11], gastric cancer [ 12], head and neck cancer [ 13], hepatocellular carcinoma [ 14] and so on.
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The Golden Girls was a historic show: four central characters, all female and all over the age of 60! Of course, back in the '80s, it was an aberration: throughout television history, female actors have been in supporting roles mostly, with an emphasis on their youth and beauty.
This is consistent with previous studies which have corrected aberrations either throughout the experimental run [ 9, 10], or after the step [ 12].
This is known as the iterative multi-photon adaptive compensation technique (IMPACT) and is a system which takes advantage of the nonlinearity of the multi-photon process to determine, and compensate for, distortions and aberrations incurred throughout a specimen [ 21].
The most common unique aberration found throughout the metastatic samples was a gain on 6q present in nine of 23 (39%) lymph nodes.
In total, 76 aberrations were identified throughout the panel, equivalent to a mean of three per case.
Copy number aberrations (CNA) occur throughout the tumour genome and are an important mechanism in colorectal cancer development[ 23].
All cell lines showed chromosomal rearrangements with complex karyotypes and genotypic aberrations were conserved throughout late passaging of the cell lines.
Nevertheless, we and other groups reported on the existence of a field cancerization in the human breast showing that the egfr aberrations were detected throughout an individual lobule or duct within histologically normal mammary epithelium with or without adjacent carcinoma [ 17, 27- 30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com