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Through the application of a classification algorithm, we now provide the genome-wide evidence that distinct patterns of copy number aberrations exist in metastatic melanomas.
Only concordant false positive aberrations exist in S. Concordant true aberrations.
A recent global gene expression meta-analysis has demonstrated that chromosomal aberrations exist in HiPSCs [13].
All types of aberrations exist in R; therefore, we independently generated n× m binary matrices, Rc, Rn and Rf.
Taken together, in contrast to the scenario for BRCA1, these results indicate that specific BRCA2-associated genomic aberrations exist.
It has been demonstrated that more genetic aberrations exist during the process of cancer progression, invasion and metastasis [ 24, 25].
Similar(52)
We were interested to investigate which genomic aberrations existed in cases co-expressing BCL6 and MUM1, and found that the genomic characteristics of BCL6+ and BCL6− in non-GCB DLBCL were different, suggesting they belong to different subtypes of disease.
Although histological classification can separate these two subtypes, previous studies using conventional genome scanning techniques such as loss of heterozygosity analysis and comparative genomic hybridisation (CGH) have shown that differences and similarities in genetic aberration exist between SCLC and NSCLC (Girard et al, 2000; Balsara and Testa, 2002).
By applying this theory, it had been deduced that no spherical aberration exists when the isoplanatic condition is fulfilled and it was then concluded that the sine condition in the presence of spherical aberration is meaningless.
Given that driver aberrations recurrently occur around driver cancer genes whereas passenger aberrations randomly exist across chromosomes, finding recurrent chromosomal aberrations is deemed a powerful approach for discovering driver aberrations and associated driver genes.
We are therefore now pursuing a larger sample size to determine whether this would continue to support the tendency of B-cell lymphomas towards fewer chromosome imbalances, whether subtype-specific aberrations do exist, and in turn whether the total number of aberrations detected in each canine lymphoma case can be correlated with overall prognosis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com