However, a study of the serial composition of copy number variants (CNVs) in individuals without diagnosed haematopoietic disorders showed clear fluctuations in the proportion of nucleated blood cells with aberrations over time (Forsberg et al., 2012).
This wide variance in spontaneous cases suggests that the underlying genetic cause of spontaneous MPNST formation may be the accumulation of a wide assortment of genetic aberrations over time, in contrast to NF-1 MPNST formation which may be due to a few specific genetic mutations.
"People change over time.
A mid-time point of 10 14 PDs was used in the cytogenetic analyses, in order to see whether levels of aberrations varied over time post irradiation and the results of cells examined post exposure were always compared with the results for un-exposed control cells for the same time point.
Other researchers have postulated that biomechanical aberrations that persist over time may have important consequences for structural changes in the joint.
Even if a standard assay panel (a panel of mutational and/or hypermethylation targets) is designed for each tumor type, the assay would still need to be broad, as individual patients with similar cancer types may show different patterns of mutations or epigenetic changes, and some of these aberrations may change over time or be influenced by treatment.
Gliomas are believed to arise as a result of a series of genetic aberrations that slowly accumulate over time.
Although it is not possible to define expected values for some parameters, such as the percentage of specimens testing positive for influenza virus or the number of SARI cases occurring in a given facility, aberrations in the data over time or substantial differences between facilities can signal problems at a given site.
Diet-or environment-induced aberrations of genes may develop over time but are often reversible, indicating that only gene expression has changed while the actual DNA sequence remains unchanged.
However, we cannot exclude that alterations in microtubular network observed in MDD2 cells were also because of genetic drift over time; chromosomal aberrations were present in the mut-p53 as demonstrated by the tetraploidy (Galmarini et al, 2001) and centrosome amplification observed in these cells.
