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Discover LudwigThe phrase "aberration event" is not standard in written English and may cause confusion
It could be used in contexts discussing unusual occurrences or anomalies, but it is better to use more established terminology. Example: "The recent data showed an aberration event that required further investigation to understand its cause."
Exact(2)
Moreover, the peak suppressing effect largely goes away when the CN aberration event is not present in all test samples, which is a typical situation.
To control for a large number of genes being gained or lost by a large single genomic aberration event (i.e., whole chromosome loss), we also calculated the average number of SWITCHdna-defined segments and their length for each subtype, as more genomic breaks will result in more segments.
Similar(58)
The description of the "chromothripsis" phenomenon has initiated a vital discussion about clustered genomic aberration events and their role in cancer development [ 52, 55, 56].
Thus, the increased number of aberrant gene-based events in the copy number unstable subtypes was due to more frequent aberrations in the genome, rather than as a large number of genes gained or lost by a few large-in-size aberration events.
It has subsequently been used in other contexts to describe what 'used' to be considered an aberration or abnormal event, but has become so commonplace and all encompassing, that it is now considered 'normal'normal
"I'm not going to say that's an aberration or a single event," Downey said.
Indeed, perhaps one of the clearest examples of an epigenetic aberration constituting a driver event was found in the context of endometrial cancer [ 12].
In a study of OSCCs associated with betel and/or tobacco use (Chang et al, 2002), 28% of samples exhibited FHIT promoter methylation, and 36% of cancers and 50% of premalignant lesions showed aberrant RT PCR products, suggesting that FHIT aberration could be an early event in oral carcinogenesis.
The trades were not an aberration or one-time events, but appear to be part of a pattern intended to keep alive a fraud that probably began with trying to paper over some bad trades.
DNA copy number aberrations are a frequent event in many malignant tumors, leading to altered expression and function of genes residing within the affected genome region.
Silencing of the PTEN has been identified in histologically normal-appearing endometrium exposed to estrogen, 19% in atypical EH, 21% and nonatypical EH suggesting that PTEN aberrations are an early event in the development of EC 39.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com