Understanding aberrant methylation caused by smoking in a network setting provides an integrated stage for understanding complex diseases like cancer while designing potential therapies.
To this end, understanding aberrant processes during adolescent neuroreorganization may help to significantly improve etiological understanding, bolster early identification, and inform interventions.
Recent advances in understanding aberrant signaling of molecular pathways in melanoma provide the bases for the current development of novel therapies for this cancer.
Development of a seed DNA-based genotyping system for marker-assisted selection (MAS) has provided a novel opportunity for understanding aberrant reproductive phenomena such as hetero-fertilization (HF) by observing the mismatch of endosperm and leaf genotypes in monocot species.
We recently used the emerging human mammary hierarchy as a framework for understanding aberrant cell subsets that may arise during breast oncogenesis [ 7].
Recent studies on genome sequencing and genetic screens with RNAi and CRISPR technology have revolutionized our understanding of aberrant signaling networks in human diseases.
In this review, we briefly summarize iron homeostasis in mammals, and discuss recent progresses in understanding the aberrant iron metabolism in numerous cancer types, with a focus on studies revealing altered signal transduction in cancer cells.
Genetic markers and manipulation have deepened our understanding of aberrant cancer signaling, growth, and proliferation[9].
Therefore, our data help to clarify the roles of aging and female gender as risk factors for sporadic AD and advance our understanding of aberrant γ-secretase activity as a potential mechanism underlying the pathogenesis of sporadic AD.
Moreover, from our point of view, the fact that some cancer methylated genes are also frequently hypermethylated in adult stem cells is particularly important to our understanding of aberrant methylation in cancer.
Fundamental to our understanding of aberrant TNFR1 signalling is the compartmentation of the receptor.
