Aberrant system xc− function is implicated in tumor growth and survival, cancer stem cell maintenance, drug resistance, and neurological dysfunction (Okuno et al., 2003; Buckingham et al., 2011; Ishimoto et al., 2011; Yae et al., 2012; Timmerman et al., 2013); inhibition of system xc− may prove useful in a number of therapeutic contexts.
Aberrant microvascular systems in solid tumors result in hypoxic regions where the O2 concentrations can approach anoxia.
This extent of dependence upon aberrant signaling systems in cancer implies that shutting down the signaling would cause the cancer to vanish.
22 The wide range of known cellular functions involving the p97 enzyme underscore the importance of developing selective p97 inhibitors, which would be highly useful to better understand the precise function of p97 in normal and aberrant physiological systems.
Ask anyone with lupus, multiple sclerosis or other diseases caused by an aberrant immune system.
Slavery was not an aberrant, patchwork system that consigned a few million luckless blacks to hard, unpaid labor.
If multiple strains of AIV are present in the cloacal swab, one subtype commonly outgrows the others in the aberrant host system (such as embryonated chicken eggs) while the other strains remain undetected [7], [24].
Ulcerative colitis (UC) is a chronic, inflammatory disease of the colonic mucosa caused, in part, by an aberrant immune system.
These particular signalling molecules are involved in PD pathophysiology, but are also very important in an aberrant coagulation/hematology system.
It is also well known that these particular signalling molecules that are involved in PD pathophysiology are also very important in an aberrant coagulation/hematology system (3).
