Your English writing platform
Discover LudwigExact(1)
More recently, several studies performed in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) revealed an aberrant frequency and/or function of Tregs thus indicating their crucial role in human diseases [18], [19], [55], [56], [57].
Similar(59)
Mohty et al. previously reported the aberrant frequencies of DCs in cryopreserved AML samples [ 16].
Whereas the aberrant frequencies of precursor and terminal plasmacytoid DCs resolved during remission, the myeloid DC compartment did not fully recover.
Due to the high variability in the frequencies of cells with mDC immunophenotype, we considered an "aberrant" mDC frequency for those samples showing mDC frequencies equal or greater than 10% of the total viable cells included in the analyses (thus, roughly corresponding to tenfold higher than the normal mDC frequency observed in healthy controls).
This suggests that variable SUMOylation within pachytene cells does not reflect aberrant recombination frequency.
A remarkable proportion of AML samples had an "aberrant" mDC frequency (42% for ITD+ and 38% for ITD−).
With an approach similar to that described by Nielsen et al. [ 33] to detect regions with aberrant allele frequency spectra (test 1), we applied a composite likelihood test to detect regions with aberrant "iHS spectra".
In consequence, the study underlined the role of miRNA disturbances in the pathogenesis of human diseases and, indeed, identified a number of SNPs with an aberrant allele frequency in human cancers.
In view of our current results, ITD+ AML samples seem to demonstrate an even more pronounced pattern of aberrant DC frequencies than ITD− AML samples.
This link between classifier performance and low frequency aberrant expression is further developed in Methods S1.
In contrast to the t test, Messina could be tuned to detect low frequency aberrant expression.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com