In contrast, COMP-MED patients seem to experience more clinical symptoms in childhood, and are more likely to develop early onset osteoarthritis of the hip due to aberrant development.
While the in vivo and in vitro conditions for pre-implanted embryo development are different, the in vivo environment may correct the aberrant development from the 2-cell stage onwards to some extent.
Disruption in RA signaling or vitamin A deficiency (VAD) has been linked to aberrant development of the lung including alterations in the airway smooth muscle (SM) differentiation, development, and function.
Schizophrenia is considered a neurodevelopmental disorder, but whether the adolescent period, proximal to onset, is associated with aberrant development in individuals at clinical high risk (CHR) for psychosis is incompletely understood.
Deletion of Fn1 using the Isl1Cre strain resulted in defective formation of the 4th pharyngeal arch arteries (PAAs), aberrant development of the cardiac outflow tract (OFT), and ventricular septum defects.
However, some maturational changes were altered, i.e. LV/HF and HV/LF incidence and duration, and likely regulated and adaptive with a decrease in the brain's nonessential energy needs, while some were altered, i.e. IV/F incidence and duration, and state transition times, and likely indicating a degree of aberrant development in associated control circuitries.
Adolescents with ASD have an aberrant development in the neural correlates responsible for social cognition.
Thus, identifying regulatory networks can provide insight into aberrant development and cancers that result when regulation is disrupted.
Furthermore, aberrant development of these prominences is a major factor in human orofacial clefting and other craniofacial birth defects.
