The phrase "aberrant delivery" is correct and usable in written English.
It can be used to describe a delivery that deviates from the expected or normal standards, often in a negative context.
Example: "The aberrant delivery of the package raised concerns about the reliability of the shipping service."
Alternatives: "deviant delivery" or "irregular delivery".
Hypoxia arises from the combination of high metabolic and proliferative rates, that is consumption and aberrant tumour vascularisation with poor oxygen delivery (Semenza, 2014).
Additionally, in the face of the natural biological barriers to the delivery of drugs, tissues with aberrant pathology, such as tumors, are often very efficient in harnessing active biological mechanisms for high nutrient supply and rapid growth.
Murine gene knock-out studies have shown that parturition is adversely affected by aberrant expression of this gene, impeding cervical ripening and fetal delivery as a result of elevated progesterone levels in the cervix [ 92].
Hypoxic tumors tend to exhibit rapid growth and aberrant vasculature, which lead to oxygen (O2) depletion and impaired drug delivery.
The practice of vessel normalization advocates the necessity of aberrant and tortuous tumor vasculature to be pruned and normalized aiding in delivery of required therapeutics and oxygen, leading to reduced hypoxia and faster tumor regression [ 10, 33].
Targeted gene knockdown via siRNA delivery has exciting potential for the treatment of diseases caused by aberrant gene expression.
By exploiting aberrant native vasculature and unique tissue markers, it is possible today to target the delivery of a given drug to the disease site.
The goal of the current study was to engineer cartilage and bone constructs with the ability to inhibit aberrant inflammatory processes caused by the cytokine interleukin-1 (IL-1), through scaffold-mediated delivery of lentiviral particles containing a doxycycline-inducible IL-1 receptor antagonist (IL-1Ra) transgene on anatomically-shaped CDM constructs.
For reduction in mature microRNA levels (due to mutation or any other mechanisms like defects in processing machinery or aberrant transcription), the therapeutic approach could be to exogenously deliver synthetic double-stranded hairpin by complexing with lipids or delivery proteins.
Here, we discuss how drug delivery and therapeutic efficacy are greatly hindered by barriers presented by the vascular endothelial cell layer and by the aberrant nature of tumor blood vessels in general.
