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Proteins in clusters 5, 8, and 9 displayed aberrant abundance resulting from loss of C7, which was normalized by losartan treatment.
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Knowledge of normal and aberrant protein abundance at the proteome level, together with pathway-centered analyses of adverse health effects in diverse population, will continue to drive the development of mechanistically based biomarkers of health status.
Again, to emphasize, the proteins encoded by such low abundance, aberrant, foreshortened transcripts may still be functionally important.
Some studies examining specific epigenetic features of embryonic and cancer stem cells—such as the aberrant DNA-methylation, abundance of modified histones, Polycomb group (PcG) protein binding patterns, replication timing, and chromatin accessibility have provided important insights into the unique properties of stem cells.
The increase of aberrant DNA methylation abundance in the late leukemic stage cannot simply be explained by the mere increase in blast counts, but might rather be the consequence of a vigorous 'epigenetic' clonal evolution or of severe disturbance of the epigenetic machinery.
RNA decay adds a new dimension to the regulation network by changing the abundance of transcripts and removing aberrant RNA molecules and intermediates of transcription and processing.
2. The genotype is abundant in the tumor tissue (abundance of aberrant DNA methylation).
In addition to validating putative substrates, we also examined several candidate non-substrates for changes in protein abundance or aberrant shedding arising from BACE1 expression.
Similar K8 and K5 histological analysis of sections derived from Dox-treated male TetO-Dkk1 mice revealed almost a complete loss of normal cTEC organization and an abundance of aberrant cystic structures (Figure 5, J *), while identically treated ST male littermate mice showed a normal distribution and morphology of both cTECs and mTECs (Figure 5, E).
All cases evaluated exhibited an abundance of aberrant bi-armed chromosomes.
Its abundance and aberrant expression in many cancers suggests that it plays an important role in the development of cancer.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com