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The phrase "abdicate their quest" is correct and usable in written English.
It can be used when discussing someone giving up or renouncing their pursuit or goal.
Example: "After years of searching for the lost treasure, the explorers decided to abdicate their quest and return home."
Alternatives: "give up their pursuit" or "renounce their mission."
Exact(1)
Matthiessen is scrupulous in his endeavour, mediated through Olin, to map the complex inheritance of the camps, resisting attempts to frame the "huge cold crimes" which saturate the landscape; yet ultimately both author and protagonist choose to abdicate their quest for a deeper intellectual response in pursuit of more consoling narratives: family, love, religion.
Similar(59)
The richer regions cannot abdicate their concern.
Governments cannot, as this one has, abdicate their responsibility for helping others to shape the future.
We're not paying our representatives to abdicate their responsibility and judgment.
Nor in the future will we allow them to abdicate their responsibilities".
Fund managers who take their cues from stockmarket indices also abdicate their roles in making markets efficient.
They tended to abdicate their financial roles when it came to planning for the future, saving and investing.
"Yes, hacking is wrong, but that is not an excuse for companies to abdicate their security obligations.
Those whom the poet does judge — and judge harshly — are leaders who abdicate their responsibilities, to principle and to their people.
RIM will have to abdicate their "prosumer" segment — not that there's much to abdicate.
"It's imperative to take the fans' thoughts into it but the SFA cannot abdicate their responsibility: they have to accept their position of responsibility".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com