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Bird and collaborators [ 24] had shown that helper T cell differentiation is controlled by the cell cycle, and other authors have reasoned that the cell cycle and DNA synthesis, in particular, would provide a window of opportunity to remodel genes from an inactive to an active state in naive T cells [ 25].
Hence mitosis might be viewed as a window of opportunity for remodeling the transcriptional landscape, which implies that putative bookmarking mechanisms remain sufficiently flexible to permit changes in cellular fate or differentiation.
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