The interaction of calcium signaling with the cAMP-pathway via regulation of adenylyl cyclase [ 145] suggests a rather widespread function of calcium in regulation of cellular events.
Here we show that dysbindin-dependent regulation of surface receptor expression is not restricted to neurons or to the D2 receptor, and identify an apparently widespread function of dysbindin in regulating GPCRs by promoting their sorting to lysosomes after endocytosis.
These results identify a distinct, and potentially widespread function of dysbindin in promoting the sorting of specific GPCRs to lysosomes after endocytosis.
The widespread function of miRNAs has been a target of several other studies in the pursuit of novel cancer treatments.
Because of the widespread function of glycosylation, inherited disorders of glycosylation are multisystemic.
This apparent widespread function of snoRNAs in gene silencing cannot be explained by their well-established involvement in the splicing machinery and in rRNA modification.
Given the widespread function of Pin1 in mammalian cells, it seemed plausible that Ess1 in yeast may regulate pathways in addition to those involved with RNAPII.
The widespread functions of ZEB proteins in human malignancies indicate their significance.
The widespread functions of Cdk5 in nervous system development have confounded efforts to understand the role of mammalian Cdk5 in neurodegeneration in vivo.
While there has been much effort to predict and characterize conserved freestanding sRNA genes, there is increasing evidence for widespread functions of conserved 3′ UTR-embedded sRNAs.
