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Furthermore, the sHFE isoform secretion was verified to occur (in addition to HepG2 cell line) in other diverse types of transfected cell lines (HuH7, HeLa, HEK293 and CaCo-2), which suggests that it is a widespread event.
Here we demonstrate that WIF1 downregulation is a widespread event in human salivary gland CaExPA.
The presence of the Apo10 epitope in OSCC and other neoplasias is a widespread event.
In this study, we found that WIF1 downregulation is a widespread event in CaExPA and its downregulation in PA might predict higher risk of progression to malignancy.
Here we report for the first time that downregulation of the Wnt inhibitory factor 1 (Wis1) is a widespread event in salivary gland carcinoma ex-pleomorphic adenoma (CaExPA).
More recently, where global analyses have been applied, all classes of tumour analysed have shown high levels of methylation of many genes, suggesting that this is a widespread event in cancer development (Martin-Subero et al, 2009; Richter et al, 2009).
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Moreover, the recent demonstration of recombination in an increasing number of NoVs suggests that it is a more widespread event than was previously realized.
Considering the unusually complex structural features of the P450 genes in this genome, including microexons (2 10 aa) and frequent small introns (45 55 bp), alternative splicing, as experimentally observed for CYP63, may be a more widespread event in the P450ome of this fungus.
Our finding that over 80% of an unbiased population of thiol-containing yeast proteins have the capacity to become significantly oxidized under physiologically relevant growth conditions suggests that reversible cysteine oxidation, such as that detected with our OxICAT method, is a much more widespread event than previously anticipated.
Globally, coral reefs are undergoing a widespread bleaching event, driven by the El Niño phenomenon and climate change.
Earlier this month, Andy Street, the boss of John Lewis, called on fellow retailers to rein in Black Friday promotions this year and ensure the day was focused on electrical goods rather than becoming a widespread discounting event affecting fashion, homeware and other categories.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com