Sentence examples for a widespread effect of from inspiring English sources

This connection hence indicates a widespread effect of the action of ENVOY.

A widespread effect of HDAC inhibitors on microRNAs (miRNAs) levels was first reported in the breast cancer cell line SKBr3.

Indeed, previous evidence from this laboratory indicated a widespread effect of the local (in mPFC) and systemic application of DOI in a proportion of VTA DA neurons that exceeded by and large the low abundance of mesocortical neurons (Bortolozzi et al. 2005).

By comparing the median substitution rates between Z and all macrochromosomes [ 51] (see Methods), we estimate that the degree of male mutation bias α ranges from 1.60 (95% confidence interval 1.34 ~ 1.92) in Sunbittern to 3.78 (2.94 ~ 5.07) in Ostrich, confirming a widespread effect of male-driven evolution among avian lineages.

A widespread effect of aging was increased expression of inflammation and immune response genes, which involved class I MHC genes (e.g., H2-D1, H2-K1), immunoglobulin chain components (e.g., Igk-V1, Igh-6), and a large module of 40 co-expressed genes known to participate in inflammation and immune processes (see Figures 5 and 6; Additional File 10).

RNA degradation pathways, also indicated to be significantly affected across the study may potentially have a widespread effect on integrity of messenger RNA of blood cells, and defective monitoring and removal of missense mRNA may result in the production of dysfunctional proteins in cells.

In summary, we have demonstrated that the early response to T. cruzi infection has a widespread effect on the expression of host genes involved in cellular defense mechanisms, stress responses, and metabolism.

Gene conversion therefore has a widespread effect on the dynamics and diversity of duplicated Y chromosome microsatellites contained within palindromes.

Importantly, differences in assemblage structure (e.g. differences in total abundances) between habitats across the latitudinal gradient were especially accentuated on the in-shore reefs compared with the off-shore reefs, where a general amelioration of differences between habitats was observed, probably associated with a more widespread effect of stronger wave forces across habitats.

It is a fairly straightforward history of the failure of these approaches to have a widespread effect (given the large areas of rangeland).

Despite a potential widespread effect of HDAC inhibition on key processes as cellular differentiation and development, many of these compounds are well tolerated in humans and some of them show therapeutic promise in a wide range of diseases, including cancer, metabolic and neurological diseases [12], [13].