The phrase "a widespread clinical problem" is correct and usable in written English.
It can be used to describe a medical issue that affects a large number of people or is prevalent in a particular population.
Example: "Obesity has become a widespread clinical problem that requires urgent attention from healthcare professionals."
Alternatives: "a common clinical issue" or "a prevalent medical concern".
The use of honey especially for wound dressing has been reported in United Kingdom and this is attributed to antibiotic-resistant bacteria which have become widespread clinical problem [ 22].
The lack of effective biological treatment for the widespread clinical problem of IVD degeneration is directly related to our limited understanding of the mechanisms regulating the processes of disc development, maintenance and degeneration.
Since meibomian gland dropout is highly correlated with changes in lipid quality and frequently observed in human subjects over the age of 50[ 1, 4, 28- 30], study of this mouse model may help in identifying underlying pathogenic mechanisms of ARMGD and suggest novel and more effective therapeutic strategies for this widespread clinical problem.
Diabetes mellitus (DM) is a widespread clinical and public health problem in many countries in the world, especially when we take into account its high prevalence, increasing morbidity and impact on health care systems in terms of costs.
Although the exact prevalence of steroid-related diabetes is unknown, the widespread use of GCs indicates that it may represent a major clinical problem worldwide.
However, many ErbB2-positive cancers exhibit intrinsic resistance, and the widespread development of acquired resistance to ErbB-targeted agents remains a substantial clinical problem.
Given the widespread occurrence of coronary atherosclerosis in the human, myocardial ischemia is a huge clinical problem.
Other potential factors may include concurrent use of drugs that interact with VKAs, thereby increasing the risk of serious bleeding, which is a widespread problem in clinical practice.
