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Lectins are a widespread class of proteins implicated in many essential cellular and molecular recognition processes.
Carotenoids are a widespread class of compounds having important functions across living organisms, whose accumulation shows striking phylum- and genotype-specific regulation [ 9].
Polychlorinated biphenyls (PCBs) are a widespread class of persistent organic chemicals that accumulate in the environment and humans and are associated with a broad spectrum of health effects.
Specific genes targeted included blaNDM-1; blaOXA (a widespread class D β-lactamase gene); and three common tetracycline resistance genes, tet(Q), tet(W), and tet(M) found in human and other mammalian guts.
The GSTP1 enzymatic activity has been shown to differ between isoenzymes with Ile or Val in amino acid position 105, with Val105 enzymes having a higher catalytic capacity for polycyclic aromatic hydrocarbons, which represent a widespread class of environmental pollutants, but a lower conjugation capacity for, among others, 1-chloro-2,4-dini-trobenzene (Sundberg et al. 1998; Watson et al. 1998).
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Ken Purchase, the former MP for Wolverhampton North East, who has died aged 77, was one of the last of what was once a widespread category of working-class Labour MPs who represented the area in which he was born, having secured election to parliament with an established experience in town-hall politics and a career working in local industry.
Alternative splicing (AS) involving tandem acceptors that are separated by three nucleotides (NAGNAG) is an evolutionarily widespread class of AS, which is well studied in Homo sapiens (human) and Mus musculus (mouse).
It has been shown that AS involving alternative donors/acceptors separated by 2-12 nt, also called "subtle alternative splicing" (due to the small difference in length in the transcript isoforms), is an evolutionarily widespread class of AS among animals, and among these, NAGNAG AS, involving acceptors separated by 3 nt, is the most common [ 5- 8].
Using sequence profile analysis and sequence-based structure predictions, we define a previously unrecognized, widespread class of P-loop NTPases.
In the second stage (1920 1950), smoking increased sharply, and reached more than half of the male population in most societies, while smoking among women increased to around 20% and became a widespread middle class and later working class habit.
Besides completely functional and non-functional alleles, we have found a widespread allelic class with intermediate functionality.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
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