Blood samples collected from the cloned lambs after birth revealed a wide range of abnormalities indicative of kidney and liver dysfunction.
There is a wide range of abnormalities which affect the skull base within the sella turcica, ranging from a persistent craniopharyngeal canal to trans-sphenoidal and sphenoethmoidal cephaloceles, many presentations of which are extremely rare.
In familial ALS (FALS) with Cu/Zn superoxide dismutase (SOD1) mutations, the mechanisms by which the mutation in SOD1 leads to such a wide range of abnormalities remains elusive.
Although the obese phenotype covers a wide range of abnormalities depending on the amount, distribution and causes of accumulated fat, most studies have defined obesity as a prepregnant body mass index (BMI = weight[kg]/height[m]2)≥30 and analyzed the entire group of obese individuals together.
Surviving mice present a wide range of abnormalities (see [ 37] for a review).
There is a wide range of abnormalities described in the spine of AS patients.
Both types of mutant embryos displayed a wide range of abnormalities, among which the formation of free asters was one of the most frequent phenotypes detected in about three-quarters of the laid eggs.
Schizophrenia is characterized by impaired social and occupational functioning and manifests as a wide range of abnormalities in perceptual, emotional, cognitive, and motor processes that cluster in three categories (Lewis and Sweet 2009): (1) positive symptoms which include delusions, perceptual disturbances and hallucinations, and abnormalities in the form of thought.
Symmetrical distal sensorimotor polyneuropathy (DSPN), the most common form of peripheral neuropathies in patients with diabetes, is a heterogeneous disorder covering a wide range of abnormalities that affect peripheral sensory and motor nerves as well as the autonomic nervous system (2).
Clearly, this would require redefining the scope of the screening (also in the pretest information and consent procedures) as targeting a wider range of chromosomal abnormalities than Down syndrome and other common autosomal aneuploidies.
