The community occupies a homogenous environment represented by a matrix of K equally accessible habitat patches within a wider meta-community of Km patches.
In this scenario, the study could serve to generate pilot-data to assist the planning of a future follow-up study, and/or to contribute a wider meta-analysis of other, sufficiently similar studies.
As we are not defining these concepts using the familiar school institutions, the boundaries of this wider meta level may or may coincide with what might be called the "school system" (which itself is not precise as it may refer to, say, a state system or to something larger like a national system).
For DNA biomarkers, the discovery phase might be a GWAs, a genome-wide meta-analysis or even a whole genome sequencing study.
Lastly, using a different panel of HLA-G imputed SNPs from a genome wide meta-analysis in an independent dataset, multiple SNPs in the HLA-G locus were significantly associated with MS susceptibility after adjusting for HLA-DRB1*15:01.
For myopia genetics in general, performance of a genome-wide meta-analysis is a logical next step.
A second locus near WNT4 (rs7521902) was found after meta-analysis with published results from a Japanese GWAS of 1423 cases and 1318 controls (4); a genome-wide meta-analysis confirmed the two loci and found a further five (5).
In line with other complex diseases [ 27], the results remain consistent with the polygenic paradigm and suggest that while much of the genetics of MS remains to be characterized, up to 350 independent variants account for a significant fraction of the genetic component of MS. A genome-wide meta-analysis of MS was recently completed and reported [ 24].
Using these data, a genome-wide meta-analysis of expression patterns for all predicted rice kinases have been performed and identified kinase-encoding genes with distinct expression patterns.
To date, we conducted for the first time a genome-wide meta-analysis in the context of knowledge-based networks and systematic reviews.
In addition, this cross-talk has been confirmed by a genome-wide meta-analysis study [ 11].
