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Aβ1 40 was used in this study because there is a wider differential in the relative toxicity of copper vs zinc forms of Aβ1 40 compared to Aβ1 42 (ie: only Cu-Aβ1 40 Cu-Aβ1 40n-and–40 is notrotoxic, while both Cu- and Zn-Aβ1 40 Zn-Aβ1 40toxis).
Despite the total greater exposure to the drug, FV-162 was better tolerated in mice xenograft models and displayed a wider differential activity between malignant and normal cells.
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"We will bar speculators from arable land once and for all," said the rural development minister, Sandor Fazekas, in an e-mail, noting that there is still a wide differential in farmland prices between Hungary and Western Europe.
In fact, ever since the financial crisis there has been a wide differential between Bank of England rates and what you actually pay for your home loan – and savings for that matter (currently there are no cash individual savings accounts which pay above inflation).
This case exemplifies the importance of a wide differential diagnosis when approaching endophthalmitis.
Cystic renal masses are a common entity with a wide differential diagnosis encountered by the radiologist in daily practice.
By itself, diffuse ground-glass opacification has a wide differential diagnosis, but the identification of small cysts admixed within the ground glass opacity is a unique feature to DIP, seen in about a third of patients (Fig. 10) [24] 24].
A wide differential preference for the hallmark P3 proline was found between MMPs ranging from 15 to 46%, yet when combined in the same peptide with the universally preferred P1′ leucine, an unexpected negative cooperativity emerged.
There is a wide differential between the different institutions in terms of training of REC members.
For example, the 'limping child' as a core presentation is ideal, as a common presentation to primary and secondary care, with a wide differential diagnosis [ 3].
In a clinical setting, however, we may expect a wide differential response, in part depending upon the genomic profile of each patient [ 48, 49].
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