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CD44 proteoglycans are involved in a wide spectrum of physiological functions such as cell cell and cell matrix interactions, morphogenesis, cell migration, cellular differentiation and tumorigenic process.
Both mechanisms are thought to enhance the diversity of FMRFamide-like peptides in order to serve a wide spectrum of physiological functions.
Because CD44 is involved in a wide spectrum of physiological functions, its dysregulation has been implicated in progression of a variety of cancers [ 6], including breast cancer.
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Human cortisone or mouse corticosterone refers to glucocorticoids, produced by the cortex of the adrenal gland and known for their hormonal regulation of a wide spectrum of physiological processes, including metabolic, cardiovascular, and immunologic functions.
Bovine M-SAA3 was differentially expressed by the mammary epithelium in response to PRL, which regulates a wide spectrum of physiological processes, such as mammary gland development, lactation, and immune function; thus, M-SAA3 has an important tissue-specific function during lactation and mammary infection [ 61].
TNF receptor plays an important role in regulation of a wide spectrum of physiological process including the immune response.
Controlled programs of exercise have long been known to provide a wide spectrum of physiological benefits to aging humans and other animals.
Thus, prostasin is implicated in a wide spectrum of physiological and pathophysiological conditions.
Members of the TNFR superfamily mediate a wide spectrum of physiological and pathological events such as cell activation, proliferation, inflammation, and cell death.
Protein tyrosine phosphatases (PTPs) are key regulators of the cellular protein phosphorylation balance, critical in the control of a wide spectrum of physiological processes such as cell proliferation, differentiation, transformation, transport and locomotion.
These genes are involved in a wide spectrum of cellular functions.
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