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Conjugation of a wide range of structurally different amines including the amines with enhanced biological activity were studied in detail.
Identifying hits for a new target usually involves screening of a wide range of structurally diverse small molecules in an in vitro bioassay.
Since the BCRP effluxes a wide range of structurally diverse xenobiotic compounds from cells [12], the broad distribution of BCRP not only renders less complete distribution of drugs but also causes a poor response of cells to chemotherapeutics [13 15].
Goswami [121] synthesized a wide range of 4-substituted coumarins (60) by the reaction of a wide range of structurally diverse phenols (59) and ethyl acetoacetate (17) or ethyl benzoyl acetate (17c) in the presence of nanocrystalline ZnO as catalyst and pyridine dicarboxylic acid as co-catalyst in acetonitrile under reflux conditions (Table 17).
We find that all network properties offer support to the superiority of the GEO-3D network model to a large number of RIGs that correspond to a wide range of structurally diverse proteins, constructed using various contact types and a wide range of distance cut-offs.
In contrast, the heterogeneous polyimmunity loci contain a wide range of structurally unrelated immunity proteins.
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Reaction conditions are found general to synthesize wide range of structurally variant alkoxymethylphosphonium iodides in high yield (70 91%).
These transporters are proposed to actively extrude or compartmentalize a wide range of chemically and structurally disparate drugs and other xenobiotics, thus providing protection from these compounds.
During method development, a wide range of chromatographic conditions and structurally related positional isomer probe molecules were exploited in an effort to gain insight into the specifics of the separation mechanism.
PXR is a ligand-dependent transcription factor with agonists and antagonists encompassing wide range of structurally diverse endogenous and exogenous compounds.
MRP2 has been found to be overexpressed in several types of cisplatin-resistant cell lines [ 25] as a potential factor involved in ATP-dependent active efflux of the wide range of structurally unrelated cytotoxic agents.
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