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Protein kinases transduce signals to regulate a wide array of cellular functions in eukaryotes.
Fungal systems, in particular the budding and fission yeasts, have been important players in unravelling the basic structural and regulatory elements involved in a wide array of cellular processes.
Classical HSP90 inhibitors bind isolated HSP90, without the need for co-chaperones being present, are characterized by their cytotoxic effects, are systemically toxic, particularly to the liver, and broadly inhibit client kinase protein binding, thereby exerting widespread effects upon cellular signaling and affecting a wide array of cellular processes15.
Chromodomain helicase DNA binding proteins (CHD) represent a class of ATP-dependent chromatin remodelling enzymes that contribute towards invoking changes in the interaction between DNA and nucleosomes24, influencing a wide array of cellular processes such as replication, transcription, recombination, repair and development25.
With respect to the 2D barcodes, OW MIMO links are currently used on a wide array of cellular telephones in the form of barcode readers.
Mechanostimuli of different cells can affect a wide array of cellular and inter-cellular biological processes responsible for dental implant healing.
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Using this approach, a wide array of different cellular environments mimicking various tissues in the body could be used to more realistically screen cancer cells for their responses to potential drugs, allowing the right drug regimen to be selected for treating a specific patient's type of cancer and its location.
A wide array of biochemical, cellular, and whole-organism markers have been applied to evaluate the biological effects of different types of pollutants in aquatic animals and assess the status of marine ecosystems.
In fact, such a technique, called RNA-Seq, is well established [ 15, 16] and similar techniques are applicable to measuring RNA structures and interactions with a wide array of important cellular molecules (Fig. 4).
A wide array of biochemical, cellular, and whole-organism markers have been applied to evaluate the biological effects of different types of pollutants in aquatic animals and to assess the status of marine ecosystems [ 31, 32].
In addition, target identification has produced a wide array of viral and cellular targets that inhibit HIV-1 replication upon silencing.
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