µLAS appears to be suitable for a wide array of molecular biology assays.
With a wide array of biomedically relevant assays now established in zebrafish [4], the advantages of this in vivo system for natural product discovery should facilitate the systematic identification of a new generation of bioactive natural products with potential utility in drug discovery.
The YKO collection has been used in a wide array of genome-wide phenotypic assays aimed toward increased understanding of biological function, response to stress, and mechanism of drug action.
This group also determined that PRIMA-1 could restore DNA binding in electromobility shift assays to a wide array of mutants that included both DNA contact (R248, R273) and conformational mutants (R175H) [ 31].
Ideally, sperm function tests should incorporate a wide array of functions in a single assay; however, evidence published to date indicates an apparent dominance of HZA in the context of clinical significance.
With further validations and benchmarking, we expect broad applicability of this protocol to a wide array of blood-based diagnostics and live-cell assays, for instance neutrophil transcriptomics28 and functional studies for the noninvasive monitoring of immunotherapy.
Proteins that are biomarker candidates from discovery phase research can be assayed with SRM peptides to facilitate experimental and clinical studies across a wide array of diseases.
Comparison with a capture-based next-generation sequencing assay showed that there is >95% concordance among a wide array of variants across a range of allele frequencies.
To validate this observation, we performed competitive binding assays with (H -E2 (see Supplemental Material, Figure S1 and Table S2), wH -E2seewed a wide array of affinitieSupplementaloMaterialomolar to micromolar values.
