Sentence examples for a wholesale modification from inspiring English sources

And if it turned out that the theory of natural selection could only be integrated with our new understanding of the processes of inheritance and development by a wholesale modification of its foundations, it might be best to see the new theory as a modified descendent of Darwinism, rather than Darwinism itself.

Mutations in fundamental biosynthetic pathway genes have been studied and reported to lead to differences in xyloglucan polymer composition in all three domains; this type of wholesale modification also tends to produce altered morphological and/or growth phenotypes [ 36, 49, 50], which is not what was observed in the plants studied here.

The power to make rapid, wholesale modifications in 3-D rested mostly with big architecture firms or companies the size of Boeing, which designed its entire 777 digitally using Dassault's Catia software.

However, differences in DNA methylation due to differential expression of DNMT1 and UHRF1 would potentially occur as minor changes rather than active, wholesale modifications in DNA methylation status.

Davis wasn't simply attempting a demographic shift but wholesale behavioral modification.

Then there was a wholesale clear-out.

Blue Hill soon became a wholesale client.

They own Lery Diamonds, a wholesale business.

I work at a wholesale distributor.

It became a wholesale and distribution centre.

In 2011, the panel recommended that "exceptions and modifications" be made to GAAP for private companies, but advised against "a separate, self-contained GAAP for private companies or a wholesale reorganization of GAAP".