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The need for a PAT to recognize substrates that lack a well-defined consensus sequence might result in some sacrifices in terms of specificity.
The GPI-SP consists of a hydrophilic region (5 10 amino acids) followed by a hydrophobic sequence (15 20 amino acids), but overall lacks a well-defined consensus sequence.
In these instances for the MS proteomics studies, evidence of phosphorylation by specific protein kinases typically includes a genetic requirement for the phosphorylation in vivo in combination with a match of the site to a well-defined consensus sequence.
These HTP studies also added evidence for phosphorylation by specific protein kinases, typically based on a genetic requirement for the phosphorylation in vivo in combination with a match of the site to a well-defined consensus sequence.
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By that point, Obama and the Democrats had come to a firm, well-defined consensus on what a new system would look like.
Variability within these sequences is not due to random mutations within one consensus sequence but to two or more well-defined consensus sequences.
The well-defined consensus sequences at the 5' and 3' splice sites do not contain sufficient information to accurately identify bona fide splice sites [13], suggesting that additional sequence features are involved in the recruitment of the spliceosome to the correct location.
These graphics have a well-defined defined color palette and trippy handwritten typography.
Furthermore, a well-defined clinical diagnosis based on consensus criteria and blinded for MRI should be used as a reference standard.
Deletions are typically large and mapping efforts have thus far not lead to a well defined consensus region, which hampers the identification of positional candidate tumour suppressor genes.
There is general consensus that a well-defined study protocol leads to fewer protocol amendments, and thus a decrease in the final trial cost [ 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com