Sentence examples similar to a well-defined alteration from inspiring English sources

Mouse models with specific genetic modifications in the components of these pathways allow us to probe the ramifications of well-defined alterations with an eye toward parsing endophenotypes of pathological conditions and behaviors.

Well-defined alterations include the constitutive activation of Ras (e.g., RasG12V) and the down-regulation of the tumor-suppressive activity of p53, which may be accompanied by oncogenic gain-of-function activity [ 1- 4].

These graphics have a well-defined defined color palette and trippy handwritten typography.

The onset of CRC is triggered by a well-defined combination of genetic alterations, which form the bases of the adenoma-carcinoma sequence hypothesis and justify the set-up of CRC screening techniques.

16, 17 The onset of CRC is triggered by a well-defined sequence of genetic alterations that form the etiological basis of the adenoma-carcinoma sequence hypothesis and justify the rationale for CRC screening.

They have a well-defined anatomic location and morphology, thus facilitating its identification and quantification, and alterations in PCs lead to ataxia, a functional phenotype that is also easy to detect and quantify.

These were then investigated in COS7 cells, as these cells have a well-defined astral MT array that radiates out from the centrosome, and thus they represent a suitable model for investigating alterations in MT organisation (Kim et al., 2004).

"You start with a well-defined state, and you end with a well-defined state.

Isn't that a well-defined problem?

"This is not a well-defined field.

A well-defined three-vessel occlusion model in the rat was performed to evaluate the capability of the proposed method in evaluating alterations to the microvasculature.