Through a detailed theoretical and spectroscopic analysis of the PIs we have shown that the phenomenon we discovered can be well rationalized by a number of crucial parameters, e.g., lifetime, transition energy, and oscillator strength of the photoinduced species.
The SAR findings revealed in this study has been well rationalized by docking simulation of the key compounds against the crystal structures of the relevant hCA isoforms.
Compared to (311), the kinetically favorable desorption of bound ethylene species from (111) surface well rationalized the higher selectivity for production of ethylene on (111) than (311).
This has been successfully achieved by establishment of a plant overall design of 672 MWe consisting of the reactor system with drastically simplified internals, the compact and double walled coolant boundaries, the well rationalized fuel handling system, the BOP systems introducing up-to-date LWR equipment, and the compact reactor building.
Most of these bonds are, however, more elusive than typical chemical bonds of organic molecules, whose nature is known and well rationalized since decades.
The use of human cell or cell lines for ligand screening can be well rationalized for eventual biomedical application.
These energetic constraints may well rationalize the small number of Arr gene clusters that we were able to detect in published genomes as compared to those of closely related enzyme systems.
While Ju and co-workers stress that the NMR enzyme models in the vicinity of the metal cofactors should be used with some caution, they point out the interesting possibility that the distinct active site geometries of the structures very well rationalize the distinct reactivities of Ni II)- versus Fe(II -ARD.
The sample size of this trial was determined by a well-rationalized calculation.
The lack of a well-rationalized dosing regimen, together with a lack of results from an appropriately designed, well-controlled study, makes it extremely difficult to develop a treatment approach with UC-MSCs.
"Well," I rationalized, "I told him to go away, and he didn't.
