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A well known function of E3 ubiquitin ligases is to target substrate proteins for degradation by the proteasome.
A well known function of class III peroxidases is lignification [ 22].
A well known function of polyamine synthesis is to provide spermidine for the hypusination of eukaryotic initiation factor 5A (eIF5A) [ 18].
Genes with high similarity at the protein level compared to Anopheles gambiae and/or Drosophila melanogaster, and which present at least one intron in the region of aligned fragments, have been preferentially selected under the assumption that they have a well known function and potentially present an intron in Lutzomyia.
In this work, we evaluated the potential link between miR-21 and one of its predicted targets, KRIT1/CCM1, a gene with a well known function in endothelial cells and in the cardiovascular system [18] and a putative role in tumorigenesis [19].
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Also, the computation process is facilitated because in these equations there are no involved integrals that must be evaluated numerically and only the well known function appears.
This finding suggests that an increase in cholesterol binding to NPC2 protein and its transport to the membrane, well known function of NPC2, is not solely responsible for papillae formation.
The well known function of Tβ4 in the regulation of the equilibrium betwen globular and filamentous actin [27] could partly explain the strong Tβ4 immunoreactivity found in the cytoplasm of enterocytes in this study.
One well known function of L-ornithine is to feed the polyamine synthetic pathway.
This is consistent with the well known function of cyclin D1 in cell cycle regulation through cyclin-dependent kinase 4/6 activation [ 3].
In addition to its well known function for accelerating cell invasion, SNAI1 has been demonstrated to contribute to enhancing metastasis by inducing immunosuppression through multiple mechanisms [ 89].
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