Sentence examples for a well known difficulty from inspiring English sources

This flexibility can be exploited to handle robustly vacuum states, which is a well known difficulty of standard Roe's method, while maintaining Roe's low diffusivity.

A well known difficulty arises from the high intensity acoustic noise produced by gradient switching in echo-planar imaging (EPI), as well as in other fMRI sequences more similar to conventional MR sequences.

A well known difficulty of zebrafish immunological research is the paucity of mAbs against zebrafish blood cells, which excludes use of fluorescent activation cell sorting, a technique sometimes used in other fish species to sort for cells of interest [45].

The distinct cross-reactivity with sera positive for antibodies against yellow fever virus is a well known difficulty for all common serological assays and is also mentioned in the instruction leaflet of the commercial test kits [ 11].

Therefore, an important practical implication of our findings is that the well known difficulty in growing primary human breast cancer cells in vitro might be alleviated by simply co-culturing the tumor cells with a monolayer of serum-activated, nonsenescent and nontransformed fibroblasts.

In spite of the well known difficulty to obtain plasma sprayed coatings containing SiC, characterisation results evidenced that the used process did not affect the phase composition.

The well known difficulty of taking into account edge effects during such measurements poses further questions as well as the effect of the density of occupation, and the seasonal variations due to clothing.

Cell-type specific loss of function experiments will be necessary to confirm the site of Robo2's endogenous activity, and our attempts to recapitulate the robo2, fra phenotype by over-expression of RNAi transgenes have so far been unsuccessful, likely because of the well known difficulty of achieving sufficient knockdown in embryonic stages.

Fine manipulation with an industrial arm encounters many well known difficulties.

Given the well known difficulties in realising 4% savings a year, leaping to 6-76-7% heroic.

But this too faces well known difficulties in the context of modern physics (see, for example, Earman 1989).