As diagnostics usually have to cope with scarce tumour material, which hardly allows satisfactory differentiation of tumour entities by morphology and heterogeneity of the material is well known, development and application of specific markers are crucial.
The effect of TSP-1 on spine number was similar to the effect of BDNF, a well known inducer of spine development in hippocampal neurons [34], [35].
Furthermore, suboptimal dosing is a well known driver for the development of antibiotic resistance during antibiotic therapy [ 8].
Although conduct disorder is a well known antecedent of antisocial development, other childhood disorders as precursors of antisociality are more controversial.
Oxidative stress is a well known factor in the development of AMD and CNV and Wang et al. showed that when the retinal sections were exposed to oxidative stress the response was an increased expression of CCR3 in the choroidal endothelial cells.
Caries in primary molars is a well known predictive factor for the development of cavities in the permanent dentition, particularly in the first molar teeth [ 36, 37].
The failure to resolve acute inflammation can lead to a chronic inflammatory state, a well known underlying component of CRC development [ 30] which is the basis for chronic low-dose preventative NSAID use [ 31, 32].
As supra-physiological intake of corticosteroids is a well known risk factor for the development of adrenal insufficiency, we investigated the function of the hypothalamic-pituitary-adrenal (HPA) axis during a 14-day course of systemic corticosteroids in patients with acute exacerbation of chronic obstructive pulmonary disease using clinical and laboratory measures.
A well known approach for assuring the whole development process is the Quality Gate approach.
According to several studies, low body condition score is a well known animal based risk factor for development of shoulder lesions [ 1, 5, 13, 14].
A well known and a very popular neural network development environment, the Stuttgart Neural Network Simulator, is used as the base for the development of neural networks.
