A trained architect, Hardwicke is a well established production designer.
The PSS is a well established measure.
PGC1α is a well-established master regulator of mitochondrial metabolism [ 1] and has previously been reported to play a protective role against a variety of neurodegenerative conditions [ 23, 24].
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Twist1 and Twist2 (Twist1–2) are two transcription factors, members of the basic helix-loop-helix family, that have been well established as master transcriptional regulators of embryogenesis and developmental programs of mesenchymal cell lineages.
Thus far, only PGC-1α (peroxisome-proliferator-activated receptor-γ co-activator 1α), the original member of the PGC-1 family of transcriptional co-activators, has been well established as a master regulator of mitochondrial biogenesis in adipocyte and muscle cell differentiation (Puigserver et al., 1998; Wu et al., 1999; Lehman et al., 2000).
SOX9 is well established as the master regulator of chondrogenesis and a factor required for the maintenance of the immature chondrocyte phenotype, and thus a potential target of RBPjk-dependent Notch function in cartilage development.
Reassuringly, well established players in the master regulatory pathways of senescence (for example p53) have also been identified in these screens [ 24, 25].
It is well established that spo0A is the master regulator for sporulation events in both bacilli and clostridia [ 5, 34].
It is well established that PPARα serves as a master regulator of fatty acid catabolism, which is also apparent from our data [ 22, 40].
